It's been marginally helpful to knock down a few of the lady Thor teams in there, but it totally flatlines on the medusa/carnage/anybody teams for some reason.
I just champed my Niko and discovered…
OML, Niko, 5* Gambit (underleveled at 405)
Gambit produces cheap red firepower, which feeds OMLs passive strike tiles, which Niko boosts. OML tanks all colors except Niko’s blue (good to transform her) and Gambit’s purple which I can avoid. I fire Niko’s yellow and OML’s black as they arise, but most of the damage is OML match and Gambit’s red. I go through whole rounds matching only OMLs red, black and yellow. It’s a bit slow on the uptake, but gains speed fairly quickly and keeps the health pack usage low.
Okoye (Warrior General) 5/*/*Medusa (Inhuman Queen) */5/*(Note: this will still work with a 1/0/0 Okoye)I'd love to suggest a third for this team, but it's completely unnecessary. This might be the biggest no-brainer, auto-pilot team anyone ever suggested. (Credit goes to @AlexNapalm for suggesting this to me over in Okoye's character thread.)Here's what you need to do:1) Make matching team-up tiles your number one priority.Um, that's pretty much it. If you do that, you should win.You see, Okoye's black passive adds damage to her teammate's powers based on how much team-up AP you have. This includes Medusa's countdown tile. It won't add damage to attack tiles, but her special countdown tile gets the bonus every turn.With 5 in black at level 270 my Okoye adds 344 damage for every TU AP in the bank. Boosted to 360 in the Deadpool PvE she was adding 650 for each TU AP. The highest I managed to get was 11 AP for +7150 damage each turn. With the 713 damage my Medusa tile does, that came out to 7,863 damage per turn.
Just to continue on my thread above, I used that team to fight the wave node in Ant-Man's growth industry where Deadpool shows up in each wave. My enemies were level 450ish. By the end I had gathered 30 team-up AP and Deadpool/Medusa's countdown tiles were doing 42k damage each.