I haven't done it yet today but am going with the Agents of S.M.A.S.H.: (L185, 5/3/5), (still L127, 5/3/5), and (L70, 2/0/1). I will, of course, let you know how it goes.
For some reason I've been having really good luck with and & .
I don't know why that would be working, other than the fact that Spider-man is good at slowing things down, and he and Storm can fire off cheap powers to get healing.
It has been very effective and I have reached the 2K mark in both seasons (a little unusal for me). Also, a big plus, I am not getting too many hits/retals.
I'm still very much a newbie so I don't have many options in the way of fun combos, but I have just managed to find a fairly fun way for me to finally manage The Big Enchilada.
Jean tanks the first couple rounds, Xavier goes invisible ASAP, and I collect black and yellow for Janet to generate tiles. When this combo takes off, it really takes off. With just a bit of luck I'm boosted enough so that rounds 3 and 4 can't even touch me. It gets dicey if a lot of board shaking stuff goes on, but I can manage sometimes even if all the protect tiles get blown up.