TPF Alexis said:
Starting off with that exception, like almost all Characters, he works better with Okoye. He can feed her yellow to heal, she can buff the damage from his Traps. This is actually also one of the situations where the Invisibility has some synergy, since while he's Invisible, he can match blue or purple without pushing her to the back and losing TU AP.
When I was down in SCL7 for the last PVE Mysterio was featured in, Mysterio/Vulture/Blonde Widow worked as well as I hoped they would (I was using the loaner Mysterio, as mine is still terrible). With her stun batons, Widow can go invisible for free, so you can easily have two characters invisible and one airborne, plus with Widow's yellow countdown active, Vulture generates 4 black and only needs 3 to take off again. Widow even makes her own yellow cheaper if you fire it the last turn before the countdown expires. Vulture is your only legitimate damage dealer, but you can't have everything, right?
I team him up with Shuri and IM40 as a fun team.
Dr. Doom 5* and Bishop. Endless way to heal Bishop. Bishop and Doom (Black) are the damage dealers, with a bit of Mysterios traps thrown in. I never stun anyone (usually) with the blue, I just let it all turn into yellow and then heal Bishop back to max health. Rinse and repeat. Isn't a fast team but I hardly ever lose in the Sim with it and rarely get attacked (thanks Bishop). I usually have to heal Bishop but Mysterio and Doom don't really take damage since Bishop soaks it all and Doom self heals. Only threats are major nukes than an take Bishop down in one turn.
Karolina Dean heals on yellow, and it adds protects to the board which can further fuel Mysterio.