It will destroy a 3x3 for each Strike tile in the match. I just tried it out with 5 enemy Strike tiles in a Match-5, and it did in fact trigger You Shoulda Run 5 times.
Sabertooths Black ability will be the ultimate Kaecilius killer.That is all.
I wish the tiles destroyed in the 3x3 of You Shoulda Run true-healed Creed for an amount equal to their match damage. It's odd to have no regen power, but I suppose he's going to have an out-of-game regen at least as fast as Wolverine. Ah well, just happy to have him in the game after all these years.
Besides 3* Patch, 3* and 4* Elektra, 3* Captain Marvel, and maybe the unreliable 3* Hawkeye, is there anyone else who gives enemy strike tiles? 3* Patch gives the most strike tiles (6) per ability activated.