Doesn't seem possible for me. 2/0/3 lvl 127.
So far no luck with my 1/1/3 at lvl 115, but its only been two tries since the PVE used up all my health packs when the sub ended this morning. Not looking great but maybe, gonna trying boosting his red tile match damage since I'll be denying him that color anyway. Waiting as along as you can does seem to be best best strategy, even if he gets a green off, it doesn't do much since there's no powers that have been used yet so no special tiles.
Tired off one yellow and 2 greens when got unlucky on health, but the greens never took out the shield tiles, so he pretty much stopped taking damage after the initial hits while I whittled away. Lowest I've gotten him so far is 5K in health.
Did stumble on any more covers for Venom, so he's still at 168 with 0/5/2 covers.
Since Carnage was at a full blown 270, I opted to use +2 R/Y, +50% R/Y, +100% All.
First attempt was a red heavy board, so I ate 3 SS's.
Won on the next attempt thanks to a pair of crits. Downed him after 2 yellows. Got a yellow IW. Ughhh.
At least I got an Iceman blue after buying a leg token.