Did it with a lvl. 128 3/2/2 Quake after 6 attempts, last two of those I used +60% all/+30% green&black/+30% blue&purple. This was a deceptively hard matchup, a few times I was cruising along nicely and the AI would cascade into a few green or blue maches which pretty much ends the game.
On my final attempt I lucked into a double match-5 on game start which did almost 7k damage, so that was the deciding factor because I ended with about 1.5k health left myself. As others have said: deny green and blue to opponent, use blue to try and remove enemy special tiles, and hope for the best because AP denial only works temporarily with IW's cheap abilities. Tokens go onto the pile (up to 10 now) until I feel there are more useful 5*s in Latest pool.
That one was surprisingly difficult even with a champed Quake.
Shows how good the Baglady rework was, really.
Champed Quake got it done first time (No ISO, so hoarding the LT)
Champed Quake and SL last season for these events - the build you "should" run is not the best build for a one-on-one.
Devs have made a boo boo here this is a total mismatch
I'll have another couple of goes but my quake is only level 168 and only have 2 covers for the covers that do damage so I don't hold out much hope