When to play PvE missions and how much?

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Have a question for vet players that's been bugging me for a while now and that is when to start Pve Missions and how much I should grind them. I've searched on the forums for a definite answer but I'm not sure people even know the best answer.

So what does everyone think? Should I start grinding all the nodes once they're full from the start? Should I clear them once a day? Do you grind them as soon as there points reach maximum again?

Thanks for all your input and help guys!