How best to level up my 5*

With the new year, it's a new focus in MPQ for me . For a while, I've been working mainly on my 4* roster. But, now that I have the majority of the 4* champed, I figured it's time that I move on and work on my 5* roster.
I'm hoping to get people's opinions on what the best approach may be for leveling up my 5*.
I have the following 5* fully covered and currently sitting at Level 330::
I definitely don't have the patience to just play at status quo until I have enough ISO to champ all of my fully covered 5* at once. Heck, I don't think I have the patience to wait until I have enough ISO to champ just my top 3 all at once. For the record, I'm presuming that my top 3 are Jessica Jones, Okoye, and Thor, but will certainly welcome other opinions.
So, what are people's thoughts on how I should spend my ISO? Should I focus on any particular (set of) 5*? What is a good midterm level I should bring them to before going all out champ? (I've heard 360?) Should I level up any of the 5* that I don't have fully covered (Kitty Pride is one that comes to mind here)?
Any thoughts are appreciated. Thanks!
I'm hoping to get people's opinions on what the best approach may be for leveling up my 5*.
I have the following 5* fully covered and currently sitting at Level 330::
- Black Bolt
- Jessica Jones
- Loki
- Okoye
- Thanos
- Thor
I definitely don't have the patience to just play at status quo until I have enough ISO to champ all of my fully covered 5* at once. Heck, I don't think I have the patience to wait until I have enough ISO to champ just my top 3 all at once. For the record, I'm presuming that my top 3 are Jessica Jones, Okoye, and Thor, but will certainly welcome other opinions.
So, what are people's thoughts on how I should spend my ISO? Should I focus on any particular (set of) 5*? What is a good midterm level I should bring them to before going all out champ? (I've heard 360?) Should I level up any of the 5* that I don't have fully covered (Kitty Pride is one that comes to mind here)?
Any thoughts are appreciated. Thanks!
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But @frederec is right that matching TU tiles for Okoye is not reliable. So, I believe the ultimate PVE clearing team is Grockitty-5*Thanos. Kitty's damage buffing is gauranteed, which lets you get the quick kill, then Thanos finishes the other 2. The only problems are tile movers and a fragile Grocket. Half of PVE nodes don't have tile movers, but you can protect your strikes with clever matching and fortifying supports when they do. You can run Grocket all the way down to almost dead before using a health pack since it doesn't matter if he dies during the match.
So, new plan @HobieCat76 only champ 5*Thanos when you have a high level Kitty to pair him with. High being level 390+. Higher the better of course with Kitty
This discussion has helped a lot! I just leveled up my Kitty Pride a little more (to 330) just so I can play around a bit more with the various Kitty combos. (As an aside here, I'm currently trying out Gritty+JJ to see if JJ adds more longevity and flexibility to Gritty's innate power. JJ's red adds strikes and/or helps replenishes Grocket strikes that have been removed as the match goes on. Both JJ's and Grocket's strikes strengthens JJ's black. And, JJ's trap tiles cause its usual irritation. I probably won't get a true gauge until the new season starts, but it seems promising.)
I'm now focusing on Okoye. I like the idea of getting her, Thor, and JJ to 360 - 380 before then going full out in champing Okoye. I like that I'll be continually improving somebody, as opposed to just stockpiling ISO for one big bang. And, yes, I'll hold off with 5*Thanos till later... hopefully if/when I'm lucky enough to get Kitty fully covered and champed.
Gritty-Thanos: Fast PVE clearing
Gritty-Kraven: Anti-Grocket+Gaurdian+Medusa teams
Gritty-Dazzler: Anti-Gritty teams, but Dazzler needs to tank green
Gritty-Carnage: more resilient on defense, but Medusa counters it
Cardusa-Kitty: resilient but slower, Medusa counters it
Teams I haven't tried yet:
Gritty-Valkyrie: trigger bounty every turn for yellow => protects; and get strikes against Grocket/5* champs; and deal extra damage too
Gritty-Bishop: mentioned above
Gritty-XFDP: against grocket/5* champs
Kitty+5*Hawkeye+OML: spam red and blue CD tiles, triggering OML strikes